Chondroitin Sulfate B (CSB)- Chondroitin Sulfates present in the human body are some of the common mucopolysnccharides, bound to collagen. They serve as constituents of the connective tissue’s fundamental substance. It is considered effective for the treatment of joint pain. It not only enhances the mobility of joints but also reduces the dose of conventional anti-inflammatory drugs. Chondroitin Sulfate B (CSB) is abundant in the skin and it is also known as dermatan sulfate. Its inhibitory effects are exerted on secondary lymphoid tissue chemokine (SLC) through binding with C-terminus of SLC. Besides being found in the skin, Chondroitin Sulfate B (CSB) is also found in blood vessels, pulmonary connective tissues, tendons and heart valves. Till date, no serious side effects have been reported as far as chondroitin sulfate B (CSB) is concerned.

Glucosamine is derived from chitin found in shells of crabs, shrimp, and oysters. There is sufficient scientific evidence to prove that glucosamine sulfate is both safe and effective for treating mild to moderate osteoarthritis of the knee. Research also indicates analgesic and disease-modifying effects of glucosamine sulfate. However, this does not imply that side effects of glucosamine sulfate do not exist. Short term use of glucosamine sulfate may lead to minor side effects such as insomnia, headache, drowsiness, heartburn, constipation, vomiting, and diarrhea and in rare cases, increase in blood pressure and heart rate and palpitations. People with bleeding disorders should not take glucosamine supplements without consulting their physician. These supplements should also be avoided by those allergic to shellfish, which happens to be the primary source of glucosamine.