Cissus Quadrangularis is a plant belonging to the grape family Vitaceae. The plants of the family are characterized by the presence of climbing stems and characteristic fruit borne in bunches called grapes. The family has many species of the genus Cissus but Cissus quadrangualris is important in that extensive research has been done on the medicinal properties of its fruit. It is rich in the many biochemicals such as carotenoids, triterpenoids and vitamin C (ascorbic acid). These chemical are anti-oxidants and vitamin C is referred to as the longevity vitamin due to its benefits. It is also believed to have a healing and regenerating effect on tendons, ligaments and muscles as well as promoting weight loss.

Glucosamine is derived from chitin found in shells of crabs, shrimp, and oysters. There is sufficient scientific evidence to prove that glucosamine sulfate is both safe and effective for treating mild to moderate osteoarthritis of the knee. Research also indicates analgesic and disease-modifying effects of glucosamine sulfate. However, this does not imply that side effects of glucosamine sulfate do not exist. Short term use of glucosamine sulfate may lead to minor side effects such as insomnia, headache, drowsiness, heartburn, constipation, vomiting, and diarrhea and in rare cases, increase in blood pressure and heart rate and palpitations. People with bleeding disorders should not take glucosamine supplements without consulting their physician. These supplements should also be avoided by those allergic to shellfish, which happens to be the primary source of glucosamine.

Hyaluronic Acid or hyaluronate is an anionic, non-sulfated glycosaminoglycan distributed widely throughout connective, neural and epithelial tissues. It is also produced synthetically for its medicinal uses. Hyaluronic acid is used in eye surgery and to treat osteoarthritis of the knee; its injections into the knee joint are believed to increase the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect. It is also used in lotions for treatment of dry skin. Hyaluronic acid has been used in the synthesis of biological scaffolds for wound healing applications. It is also used in anti adhesive products to prevent postoperative adhesions in pelvic and abdominal surgery.

MSM is also known as methylsulfonylmethane. It is known to enhance the effectiveness of antioxidants and other bioflavinoids. It is used for increased alertness and ability to concentrate as well as improved mood. MSM is often used to prevent and treat muscle cramps in the legs and back due to inactivity and strenuous use. It improves hair and cuticle growth as well as reduces wrinkles from aging. This supplement also seems to help in the body's ability to produce insulin choline and speeds up the metabolizing carbohydrates.