Caffeine is a stimulant that is used to stay awake and it gives mental alertness from fatigue. This is used as an adjunct for pain relief and also as energy accelerates. Caffeine is a non-prescription drug easily available as over the counter medication and comes in combination to acquire relief from headache and pain. Caffeine increases the mental alertness by offering the required energy for exercise training and weight loss. Caffeine cannot be considered as a mere stimulant as it reaches deep into muscles and provides power that is long lasting. Caffeine taken before any work out is also great as it fights the fatigue and keeps the person ready for the workout. Dieters also find caffeine as the solution as they feel sluggish. This is a no-calorie stimulant and does its job effectively and quickly. Caffeine anhydrous is found even in one or two coffee cups. However, this limitation is recommended as excess caffeine may result in irritability, rapid heart beat, nervousness and sleeplessness.

Green Tea Extract is a widely consumed beverage in the world. It is well known for its antioxidant properties. It is traditionally used to treat ailments such as headaches, poor digestion, and body aches. Green tea extract is rich in catechin which increases the level of cholecystokinin that suppresses that appetite, thus promoting weight loss. It also contains Pheophytins, chlorophylls, caffeine, and carotenoids that have anti-genotoxic and antioxidant properties. It also helps in thermogenesis and in the metabolism of fat, promoting weight loss. The EGCG content protects the body from free radical damages. It also blocks the carcinogens that may cause cancer and protects the body from digestive and respiratory infections. It also has anti-bacterial properties.

Gymnema Sylvestre, also known as Gurmar and Meshashringi, or 'sugar destroyer'. Gymnema Sylvestre leaves have a blood sugar lowering effect. The leaf extracts also contain gymnemic acid which inhibits hyperglycemia and also acts as a cardiovascular stimulant. Gymnema Sylvestre is commonly used to remove the taste of sugar, therefor reducing cravings for sweets.

Kola Nut- The trees found in Africa have seed pods that are inherent with Kola nuts. In regions of western Africa and central Africa, Kola nut trees are commonly found and they tend to grow up to 18 meters in height which is a good 60 feet. Kola nut consists of caffeine and has acts as a powerful anti depressant and stimulant. Kola nuts importance has been realized mainly in western Africa. It is also useful in reducing indigestion, hunger and fatigue. In simple words, it functions as an aphrodisiac. According to tradition, Kola nuts are offered when someone enters their new house and it symbolizes hospitality and friendship. Kola nut can be easily found as there are several street vendors selling them at places such as the bus or train station.

Synthetic Guggulsteroneswere first intended for use as a drug and is now used as a weight loss product and weight management product with the possibility of some side effects. More studies need to be done on this.

White Willow Bark, which is often used as a natural alternative to aspirin, and is best not to be used by individuals allergic to aspirin. White willow bark extract offers little benefit to weight loss by itself but when used with other dietary supplements, it is thought to work as a thermogenic and help to elevate energy expenditure and promote the metabolsim of fat.

Yerba Matte- Described as an ancient drink of friendship derived from a small shrub. It is sometimes spelled as yerba mate and people drink it in order to gain energy producing properties without consuming caffeine as they would in normal tea or coffee. People believe that yerba mate is a appetite suppressant, clears the mind as well as relieving allergies, improving sleep patterns and lifting the mood, that is why it is used in Stacker 2. It is advertised as an aid to weight loss, a fortifier of the immune system, a colon cleanser and even as a means of extending life. It is prepared as an infusion, with twigs and leaves immersed in boiling water in order to produce a tisane. Traditionally it is made in a vessel which is then shared among friends.